August 2, 2013. Am J Kidney Dis. Effect of time to treatment in patients with acute coronary syndrome (ACS) who are treated with the GIIb/IIIa inhibitor eptifibatide. AstraZeneca. Low-dose vs standard-dose unfractionated heparin for percutaneous coronary intervention in acute coronary syndromes treated with fondaparinux: the FUTURA/OASIS-8 randomized trial. Sorensen JT, Terkelsen CJ, Norgaard BL, et al. They report that at baseline 21% of symptomatic staff seeking SARS-CoV-2 testing were confirmed to be infected; this rate declined to 15% after staff masking was mandated, and then to 11% after patient masking was mandated. (Anemia and hypoxemia can precipitate myocardial ischemia in the absence of severe reduction in coronary artery blood flow.). Mahaffey KW, Ferguson JJ. 335(18):1342-9. 2014 Apr 8. 2012 May 29. Antman EM, Cohen M, Bernink PJ, et al. Scheuermeyer FX, Innes G, Grafstein E, et al. Using weighted nonlinear regression, we fit the best curve for the preintervention and intervention periods (based on R2 value). [Full Text]. Stone GW, McLaurin BT, Cox DA, et al. Antiplatelet Trialists' Collaboration. J Am Coll Cardiol. Use of cardiac markers in the ED. knowing what words immediately follow and precede a word in a sentence). Predictors of poor clinical outcomes in patients with acute myocardial infarction and non-obstructed coronary arteries (MINOCA). Peak B is the cardiac troponin level after infarction. 52(5):812-8. Jamshid Shirani, MD is a member of the following medical societies: American Association for the Advancement of Science, American Federation for Medical Research, American Society of Echocardiography, Association of Subspecialty Professors, American College of Cardiology, American College of Physicians, American Heart AssociationDisclosure: Nothing to disclose. [13] OCTAVIA, which was designed to examine gender differences at the time of primary PCI, included 140 STEMI patients at 14 Italian centers, matched by age and risk factors, who received an everolimus-eluting stent. Please confirm that you would like to log out of Medscape. [9]. [Medline]. Despite these local and statewide measures, the case number continued to increase in Massachusetts throughout the study period,6 suggesting that the decrease in the SARS-CoV-2 positivity rate in MGB HCWs took place before the decrease in the general public. [Full Text]. Circulation. Bangalore S, Qin J, Sloan S, Murphy SA, Cannon CP. September 1, 2020. 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Published Online: July 14, 2020. doi:10.1001/jama.2020.12897. recommend “appealing messaging that normalizes mask wearing.”(1) However the major thrust of most arguments to persuade the public about masks is that although the recommended cloth mask may not provide virus protection to the individual wearing it, the mask can prevent transmission to others. 2017 AHA/ACC clinical performance and quality measures for adults with ST-Elevation and non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. Program within @mayoclinicgradschool is currently accepting applications! [Medline]. Requiem for a heavyweight: the demise of creatine kinase-MB. Patients with acute coronary syndrome and normal high-sensitivity troponin. Medscape Medical News. Fragmin during Instability in Coronary Artery Disease. Circulation. Diagnostic value of ischemia-modified albumin in patients with suspected acute coronary syndrome. However, the pictures and stories of US citizens ignoring the recommendations should make us reconsider that assumption. News, 2003 J Am Coll Cardiol. [Medline]. In the emergency setting, electrocardiography (ECG) is the most important diagnostic test for angina. This event is followed by platelet activation and aggregation, activation of the coagulation pathway, and vasoconstriction. Am Heart J. 2006 Jul 4. 28(7):564-8. Mayo Clin Proc. 380(9850):1317-24. 2010 Sep 22. Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. Circulation. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. J Am Coll Cardiol. 09:05 25 Oct 19. Hunter E, Price DA, Murphy E, et al. [Full Text]. [Medline]. This is one of the most important articles published on COVID-19. The city approved an agreement with Steerman Law Firm for services for 2021 at a rate of $165 per hour, the same as for 2020. Clin Chem. Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes treated with glycoprotein IIb/IIIa inhibitors or thienopyridines: results from the OASIS 5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) trial. [7], LeLeiko et al determined that serum choline and free F(2)-isoprostane are also predictors of cardiac events in ACS. Available at http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020406s076,021428s023lbl.pdf. 122(24):2619-33. Dexilant (dexlansoprazole). Smoking-cessation classes should be offered to help patients avoid smoking after a myocardial infarction. Bonaca MP, Bhatt DL, Cohen M, et al, for the PEGASUS-TIMI 54 Steering Committee and Investigators. Thadani U, Opie LH. J Am Coll Cardiol. 2011 Dec. 124(12):1151-7. 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Recorded July 14, 2020. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Third, there have been small variations in the published numbers for MA for a given date. [Medline]. 43(6):966-71. 2011 Jul. [Medline]. Accessed: January 23, 2013. J Am Coll Cardiol. As a student,…” Accessed: May 27, 2014. Coronary artery calcium scoring in the emergency department: identifying which patients with chest pain can be safely discharged home. [Medline]. N Engl J Med. These patients were enrolled in the Global Registry of Acute Coronary Events (GRACE) at 123 hospitals in 14 countries from 1999-2007. Safety and efficiency of a chest pain diagnostic algorithm with selective outpatient stress testing for emergency department patients with potential ischemic chest pain. The information will be posted with your response. [13], On initial OCT, no differences by gender were found in the proportion of ruptured or eroded plaques, thus suggesting that the pathophysiology of STEMI is nearly identical in men and women. [Medline]. ... Niraj Bhatt. Cardiac screening with electrocardiography, stress echocardiography, or myocardial perfusion imaging: advice for high-value care from the American College of Physicians. Almog R, Carasso S, Lavi I, Amir O. If the authors wish to measure the positivity rate within the population of HCWs which are susceptible to SARS-CoV-2 on the, Wearing a Face Mask is a Sine Qua Non to Stop the Pandemic, The 11% Who Contracted Covid after Universal Masking, Coronavirus Update With CDC Director Robert R. Redfield, MD. What is the optimal blood pressure in patients after acute coronary syndromes? Lopes RD, Alexander KP, Manoukian SV, et al. No compensation was received for their roles. Circulation. Acute coronary syndrome (ACS) refers to a spectrum of clinical presentations ranging from those for ST-segment elevation myocardial infarction (STEMI) to presentations found in non–ST-segment elevation myocardial infarction (NSTEMI) or in unstable angina. [Guideline] O'Gara PT, Kushner FG, Ascheim DD, et al. 2018 Sep 15. Heart. Prehospital troponin T testing in the diagnosis and triage of patients with suspected acute myocardial infarction. [Medline]. Medscape Medical News. [Full Text]. Usefulness of comprehensive cardiothoracic computed tomography in the evaluation of acute undifferentiated chest discomfort in the emergency department (CAPTURE). 345(14):1014-21. ESC’s revised NSTE-ACS guidelines embrace hsT, personalized anti-ischemia treatments. Cardiovasc Drugs Ther. to download free article PDFs, The study period is divided into 3 phases: a preintervention period before implementation of universal masking of HCWs (pink), which includes March 26, the day after implementation of universal masking for HCWs, to account for HCWs who became symptomatic after business hours on March 25 and were tested on March 26; a transition period until implementation of universal masking of patients (purple) plus an additional lag period (yellow); and the intervention period (green). 2016 Sep 6. Further study is needed to assess the effect of treatment on survival. J Am Coll Cardiol. Impact of the presence and extent of incomplete angiographic revascularization after percutaneous coronary intervention in acute coronary syndromes: the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. Heidenreich PA, Alloggiamento T, Melsop K, et al. 305(18):1863-72. [Guideline] Welsford M, Nikolaou NI, Beygui F, et al, for the Acute Coronary Syndrome Chapter Collaborators. Datasets are an integral part of the field of machine learning. Available at https://www.medscape.com/viewarticle/936676. 13:36 11 Oct 19. Cardiovascular mortality in chronic kidney disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel. Positivity rates included the first positive test result for all HCWs in the numerator and HCWs who never tested positive plus those who tested positive that day in the denominator. Morrow DA, Wiviott SD, White HD, et al. [Full Text]. The dashboard published on 4/30/2020 showed an increase/plateau of number of new cases per day, suggesting a continued level of community spread (2). 357(20):2001-15. [Medline]. An elevated level of troponin (a type of regulatory protein found in skeletal and cardiac muscle) permits risk stratification of patients with ACS and identifies patients at high risk for adverse cardiac events (ie, myocardial infarction, death) up to 6 months after the index event. Mehta SR, Yusuf S. The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme; rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease. Biomarkers in acute cardiac disease: the present and the future. Stubbs P, Collinson P, Moseley D, Greenwood T, Noble M. Prognostic significance of admission troponin T concentrations in patients with myocardial infarction. ca. JAMA. [Medline]. 59(4):256-264.e3. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Initial therapy focuses on the following: Pharmacologic anti-ischemic therapy includes the following: Beta blockers (eg, metoprolol): These are indicated in all patients unless contraindicated. 2015 ACC/AHA/SCAI focused update on primary percutaneous coronary intervention for patients with ST-Elevation myocardial infarction: an update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention and the 2013 ACCF/AHA guideline for the management of ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Optimal timing of coronary angiography and potential intervention in non-ST-elevation acute coronary syndromes. [Medline]. [Medline]. 124(5):434-43. [Medline]. 2017 Oct 17. Circulation. The exact format of this dashboard has evolved throughout the pandemic. Hughes S. New European lipid guidelines take aggressive approach. Craig T Basson, MD, PhD Gladys and Roland Harriman Professor of Medicine, Director of the Center for Molecular Cardiology, Director of Cardiovascular Research, Division of Cardiology, Department of Medicine, Weill Cornell Medical College; Attending Physician, New York Presbyterian Hospital, Craig T Basson, MD, PhD is a member of the following medical societies: American College of Cardiology and American Heart Association, Edward Bessman, MD, MBA Chairman and Clinical Director, Department of Emergency Medicine, John Hopkins Bayview Medical Center; Assistant Professor, Department of Emergency Medicine, Johns Hopkins University School of Medicine, Edward Bessman, MD, MBA is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, and Society for Academic Emergency Medicine, David FM Brown, MD Associate Professor, Division of Emergency Medicine, Harvard Medical School; Vice Chair, Department of Emergency Medicine, Massachusetts General Hospital, David FM Brown, MD is a member of the following medical societies: American College of Emergency Physicians and Society for Academic Emergency Medicine, Steven J Compton, MD, FACC, FACP Director of Cardiac Electrophysiology, Alaska Heart Institute, Providence and Alaska Regional Hospitals, Steven J Compton, MD, FACC, FACP is a member of the following medical societies: Alaska State Medical Association, American College of Cardiology, American College of Physicians, American Heart Association, American Medical Association, and Heart Rhythm Society, Gary Setnik, MD Chair, Department of Emergency Medicine, Mount Auburn Hospital; Assistant Professor, Division of Emergency Medicine, Harvard Medical School, Gary Setnik, MD is a member of the following medical societies: American College of Emergency Physicians, National Association of EMS Physicians, and Society for Academic Emergency Medicine, Disclosure: SironaHealth Salary Management position; South Middlesex EMS Consortium Salary Management position; ProceduresConsult.com Royalty Other, Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference.
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